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    Tips for Crossing Water in Your Jeep Wrangler

    Tips for Crossing Water in Your Jeep Wrangler

    4 Helpful Tips for Giving Your Car a Glossy Finish

    4 Helpful Tips for Giving Your Car a Glossy Finish

    4 Common Mistakes To Avoid With Car Restorations

    4 Common Mistakes To Avoid With Car Restorations

    Signs That It Might Be Time To Get a New Car

    Signs That It Might Be Time To Get a New Car

    Mercedes-Benz Charging Network

    Mercedes-Benz to Launch Global Branded High-Power Charging Network in North America

    Ways To Surprise Your Partner Who Loves Cars

    Ways To Surprise Your Partner Who Loves Cars

    5 Important Tips for Every New Jeep Owner

    5 Important Tips for Every New Jeep Owner

    The Best Ways To Increase the Value of Your Car

    The Best Ways To Increase the Value of Your Car

    Why Jeeps Are Awesome for Off-Roading Adventures

    Why Jeeps Are Awesome for Off-Roading Adventures

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    • Mercedes-Benz
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  • Business
    Los Angeles implemented a new tax on luxurious real estate to finance affordable housing and combat homelessness

    Los Angeles implemented a new tax on luxurious real estate to finance affordable housing and combat homelessness

    Working shorter hours: 38 companies in the USA are testing the 4-day week

    Working shorter hours: 38 companies in the USA are testing the 4-day week

    World’s largest trial in the UK: 86 percent want to keep 4-day week

    World’s largest trial in the UK: 86 percent want to keep 4-day week

    Rewarding “Good” Companies—How the Economy for the Common Good Wants to Change the World

    Rewarding “Good” Companies—How the Economy for the Common Good Wants to Change the World

    Redistributing 11 billion dollars: Colombia’s left-wing president wants to fight poverty with a wealth tax

    Redistributing 11 billion dollars: Colombia’s left-wing president wants to fight poverty with a wealth tax

    Ban or regulate: The world searches for a way to deal with cryptocurrencies

    Ban or regulate: The world searches for a way to deal with cryptocurrencies

    Bolivia: Less poverty and booming economy through nationalisation of mineral resources

    Bolivia: Less poverty and booming economy through nationalisation of mineral resources

    “Creating Prosperity Together”: How the social economy model saved the English city of Preston

    “Creating Prosperity Together”: How the social economy model saved the English city of Preston

    Amazon continues to destroy new goods and returns 

    Amazon continues to destroy new goods and returns 

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    • Fashion
      Essential Tips for Planning a Great Fashion Show

      Essential Tips for Planning a Great Fashion Show

      Signs That Your Tuxedo Doesn’t Fit Right

      Signs That Your Tuxedo Doesn’t Fit Right

      Make a Bold Style Statement With These Wide-Leg Pants

      Make a Bold Style Statement With These Wide-Leg Pants

      Power Your Winter Workouts With The Best Zip Hoodies for Men

      Power Your Winter Workouts With The Best Zip Hoodies for Men

      The Ultimate Watch Buying Guide

      The Ultimate Watch Buying Guide

      Outdoor Enthusiasts, Take Note: These Watches Are as Tough as You

      Outdoor Enthusiasts, Take Note: These Watches Are as Tough as You

      Our 7 Favorite Field Jackets for Tackling Fall Weather

      Our 7 Favorite Field Jackets for Tackling Fall Weather

      The Best Leather Jackets for Guys – No Matter Your Budget

      The Best Leather Jackets for Guys – No Matter Your Budget

      Campus-Ready Backpacks for Storing *All* the Books

      Campus-Ready Backpacks for Storing *All* the Books

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      • Food & Drink
        Cheese Tortellini in Creamy Marinara

        Cheese Tortellini in Creamy Marinara

        Unusual Products That Come From Animals and Their Uses

        Unusual Products That Come From Animals and Their Uses

        Tips for Creating a Homemade Wine Cellar

        Tips for Creating a Homemade Wine Cellar

        How the wine you choose can help you have an eco-friendly home

        How the Wine You Choose Can Help You have an Eco-Friendly Home

        Rum and Cola Holiday Ham

        Special Centerpieces for Holiday Celebrations

        ChefsGiving 2020

        This Holiday Season, How about Cooking for a Cause?

        Iced Cold Moscow Mule cocktail with lime and pomegranate

        Holiday Spirits: The Cranberry Smash Moscow Mule

        The Most Beautiful Liquor Bottles in the World

        The Most Beautiful Liquor Bottles in the World

        Tao Group Virtual Chef Experience

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        • Health
          California Confronts the Threat of ‘Tranq’ as Overdose Crisis Rages

          California Confronts the Threat of ‘Tranq’ as Overdose Crisis Rages

          Our 300th Episode!

          Our 300th Episode!

          As Medicaid Purge Begins, ‘Staggering Numbers’ of Americans Lose Coverage

          As Medicaid Purge Begins, ‘Staggering Numbers’ of Americans Lose Coverage

          Health Care Coalition Jockeys Over Medi-Cal Spending, Eyes Ballot Initiative

          Health Care Coalition Jockeys Over Medi-Cal Spending, Eyes Ballot Initiative

          How a Medical Recoding May Limit Cancer Patients’ Options for Breast Reconstruction

          How a Medical Recoding May Limit Cancer Patients’ Options for Breast Reconstruction

          Cardiovascular Disease Is Primed to Kill More Older Adults, Especially Blacks and Hispanics

          Cardiovascular Disease Is Primed to Kill More Older Adults, Especially Blacks and Hispanics

          Newsom and Democratic Lawmakers at Odds Over Billions in Health Care Funds

          Newsom and Democratic Lawmakers at Odds Over Billions in Health Care Funds

          Many People Living in the ‘Diabetes Belt’ Are Plagued With Medical Debt

          Many People Living in the ‘Diabetes Belt’ Are Plagued With Medical Debt

          A Catch-22 for Clinics: State Bans Limit Abortion Counseling. Federal Title X Rules Require It.

          A Catch-22 for Clinics: State Bans Limit Abortion Counseling. Federal Title X Rules Require It.

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          • Lifestyle

            The History and Meaning of Memorial Day

            Ways To Make Your Partner Feel Loved and Appreciated

            Ways To Make Your Partner Feel Loved and Appreciated

            Values and principles, even when faced with temptations, challenges, or potential negative consequences.

            Acknowledging Racism within Familial and Social Circles: An Examination of Cognitive Dissonance and Socio-Cultural Factors

            Definition of ethics

            The Interconnectedness of Racial Opinions and Ethics

            Sacrifice States: the US Nuclear Sponge

            woman with gun near thief at night in parking lot

            Why it’s Important to know Your 2nd Amendment Rights

            Tips for Growing a Fuller and Healthier Beard

            Tips for Growing a Fuller and Healthier Beard

            Fulfilling Side Hustles for Good Money in 2023

            Fulfilling Side Hustles for Good Money in 2023

            5 Tips on How To Run Your First Charity Event

            5 Tips on How To Run Your First Charity Event

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            • Politics
              OpenSecrets releases report on out-of-state donations’ rising role

              OpenSecrets releases report on out-of-state donations’ rising role

              Independent Sen. Krysten Sinema continues using liberal platforms to fundraise for 2024 reelection campaign

              Independent Sen. Krysten Sinema continues using liberal platforms to fundraise for 2024 reelection campaign

              Watchdog bites Ron DeSantis for alleged “soft money” campaign finance violation

              Watchdog bites Ron DeSantis for alleged “soft money” campaign finance violation

              Press Release: Over 30,000 White House financial disclosures to be made public in first for transparency and accountability

              Press Release: Over 30,000 White House financial disclosures to be made public in first for transparency and accountability

              Pro-Ron DeSantis super PAC to inherit state-level PAC war chest to support presidential run

              Pro-Ron DeSantis super PAC to inherit state-level PAC war chest to support presidential run

              Definition of ethics

              The Interconnectedness of Racial Opinions and Ethics

              Spyware firm NSO Group continues lobbying efforts to resume business-as-usual in the U.S.

              Spyware firm NSO Group continues lobbying efforts to resume business-as-usual in the U.S.

              Joe Manchin vows to block “radical climate agenda,” rakes in oil and gas industry contributions

              Joe Manchin vows to block “radical climate agenda,” rakes in oil and gas industry contributions

              Adam Schiff heads into California’s 2024 U.S. Senate race with a sizable cash advantage

              Adam Schiff heads into California’s 2024 U.S. Senate race with a sizable cash advantage

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              • Real Estate
                Ways To Invest in Real Estate With No Experience

                Ways To Invest in Real Estate With No Experience

                How To Make Your Rental Property More Eco-Friendly

                How To Make Your Rental Property More Eco-Friendly

                Things To Consider Before Investing in Real Estate Overseas

                Things To Consider Before Investing in Real Estate Overseas

                Incredible Areas in Florida To Buy a Vacation Home

                Incredible Areas in Florida To Buy a Vacation Home

                Helpful Home Staging Tips for Virtual Tours

                Helpful Home Staging Tips for Virtual Tours

                Ways To Decorate and Design a Lake House

                Ways To Decorate and Design a Lake House

                Challenges To Managing a Rental Property

                Challenges To Managing a Rental Property

                The Best Landlord: How To Show Tenants You Care

                The Best Landlord: How To Show Tenants You Care

                The Best Locations To Invest in a Second Home

                The Best Locations To Invest in a Second Home

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                • Automotive
                  Tips for Crossing Water in Your Jeep Wrangler

                  Tips for Crossing Water in Your Jeep Wrangler

                  4 Helpful Tips for Giving Your Car a Glossy Finish

                  4 Helpful Tips for Giving Your Car a Glossy Finish

                  4 Common Mistakes To Avoid With Car Restorations

                  4 Common Mistakes To Avoid With Car Restorations

                  Signs That It Might Be Time To Get a New Car

                  Signs That It Might Be Time To Get a New Car

                  Mercedes-Benz Charging Network

                  Mercedes-Benz to Launch Global Branded High-Power Charging Network in North America

                  Ways To Surprise Your Partner Who Loves Cars

                  Ways To Surprise Your Partner Who Loves Cars

                  5 Important Tips for Every New Jeep Owner

                  5 Important Tips for Every New Jeep Owner

                  The Best Ways To Increase the Value of Your Car

                  The Best Ways To Increase the Value of Your Car

                  Why Jeeps Are Awesome for Off-Roading Adventures

                  Why Jeeps Are Awesome for Off-Roading Adventures

                  Trending Tags

                  • Mercedes-Benz
                  • Mustang
                • Business
                  Los Angeles implemented a new tax on luxurious real estate to finance affordable housing and combat homelessness

                  Los Angeles implemented a new tax on luxurious real estate to finance affordable housing and combat homelessness

                  Working shorter hours: 38 companies in the USA are testing the 4-day week

                  Working shorter hours: 38 companies in the USA are testing the 4-day week

                  World’s largest trial in the UK: 86 percent want to keep 4-day week

                  World’s largest trial in the UK: 86 percent want to keep 4-day week

                  Rewarding “Good” Companies—How the Economy for the Common Good Wants to Change the World

                  Rewarding “Good” Companies—How the Economy for the Common Good Wants to Change the World

                  Redistributing 11 billion dollars: Colombia’s left-wing president wants to fight poverty with a wealth tax

                  Redistributing 11 billion dollars: Colombia’s left-wing president wants to fight poverty with a wealth tax

                  Ban or regulate: The world searches for a way to deal with cryptocurrencies

                  Ban or regulate: The world searches for a way to deal with cryptocurrencies

                  Bolivia: Less poverty and booming economy through nationalisation of mineral resources

                  Bolivia: Less poverty and booming economy through nationalisation of mineral resources

                  “Creating Prosperity Together”: How the social economy model saved the English city of Preston

                  “Creating Prosperity Together”: How the social economy model saved the English city of Preston

                  Amazon continues to destroy new goods and returns 

                  Amazon continues to destroy new goods and returns 

                  Trending Tags

                  • Fashion
                    Essential Tips for Planning a Great Fashion Show

                    Essential Tips for Planning a Great Fashion Show

                    Signs That Your Tuxedo Doesn’t Fit Right

                    Signs That Your Tuxedo Doesn’t Fit Right

                    Make a Bold Style Statement With These Wide-Leg Pants

                    Make a Bold Style Statement With These Wide-Leg Pants

                    Power Your Winter Workouts With The Best Zip Hoodies for Men

                    Power Your Winter Workouts With The Best Zip Hoodies for Men

                    The Ultimate Watch Buying Guide

                    The Ultimate Watch Buying Guide

                    Outdoor Enthusiasts, Take Note: These Watches Are as Tough as You

                    Outdoor Enthusiasts, Take Note: These Watches Are as Tough as You

                    Our 7 Favorite Field Jackets for Tackling Fall Weather

                    Our 7 Favorite Field Jackets for Tackling Fall Weather

                    The Best Leather Jackets for Guys – No Matter Your Budget

                    The Best Leather Jackets for Guys – No Matter Your Budget

                    Campus-Ready Backpacks for Storing *All* the Books

                    Campus-Ready Backpacks for Storing *All* the Books

                    Trending Tags

                    • Food & Drink
                      Cheese Tortellini in Creamy Marinara

                      Cheese Tortellini in Creamy Marinara

                      Unusual Products That Come From Animals and Their Uses

                      Unusual Products That Come From Animals and Their Uses

                      Tips for Creating a Homemade Wine Cellar

                      Tips for Creating a Homemade Wine Cellar

                      How the wine you choose can help you have an eco-friendly home

                      How the Wine You Choose Can Help You have an Eco-Friendly Home

                      Rum and Cola Holiday Ham

                      Special Centerpieces for Holiday Celebrations

                      ChefsGiving 2020

                      This Holiday Season, How about Cooking for a Cause?

                      Iced Cold Moscow Mule cocktail with lime and pomegranate

                      Holiday Spirits: The Cranberry Smash Moscow Mule

                      The Most Beautiful Liquor Bottles in the World

                      The Most Beautiful Liquor Bottles in the World

                      Tao Group Virtual Chef Experience

                      Entertain Your Guests Virtually This Fall ?

                      Trending Tags

                      • Health
                        California Confronts the Threat of ‘Tranq’ as Overdose Crisis Rages

                        California Confronts the Threat of ‘Tranq’ as Overdose Crisis Rages

                        Our 300th Episode!

                        Our 300th Episode!

                        As Medicaid Purge Begins, ‘Staggering Numbers’ of Americans Lose Coverage

                        As Medicaid Purge Begins, ‘Staggering Numbers’ of Americans Lose Coverage

                        Health Care Coalition Jockeys Over Medi-Cal Spending, Eyes Ballot Initiative

                        Health Care Coalition Jockeys Over Medi-Cal Spending, Eyes Ballot Initiative

                        How a Medical Recoding May Limit Cancer Patients’ Options for Breast Reconstruction

                        How a Medical Recoding May Limit Cancer Patients’ Options for Breast Reconstruction

                        Cardiovascular Disease Is Primed to Kill More Older Adults, Especially Blacks and Hispanics

                        Cardiovascular Disease Is Primed to Kill More Older Adults, Especially Blacks and Hispanics

                        Newsom and Democratic Lawmakers at Odds Over Billions in Health Care Funds

                        Newsom and Democratic Lawmakers at Odds Over Billions in Health Care Funds

                        Many People Living in the ‘Diabetes Belt’ Are Plagued With Medical Debt

                        Many People Living in the ‘Diabetes Belt’ Are Plagued With Medical Debt

                        A Catch-22 for Clinics: State Bans Limit Abortion Counseling. Federal Title X Rules Require It.

                        A Catch-22 for Clinics: State Bans Limit Abortion Counseling. Federal Title X Rules Require It.

                        Trending Tags

                        • Lifestyle

                          The History and Meaning of Memorial Day

                          Ways To Make Your Partner Feel Loved and Appreciated

                          Ways To Make Your Partner Feel Loved and Appreciated

                          Values and principles, even when faced with temptations, challenges, or potential negative consequences.

                          Acknowledging Racism within Familial and Social Circles: An Examination of Cognitive Dissonance and Socio-Cultural Factors

                          Definition of ethics

                          The Interconnectedness of Racial Opinions and Ethics

                          Sacrifice States: the US Nuclear Sponge

                          woman with gun near thief at night in parking lot

                          Why it’s Important to know Your 2nd Amendment Rights

                          Tips for Growing a Fuller and Healthier Beard

                          Tips for Growing a Fuller and Healthier Beard

                          Fulfilling Side Hustles for Good Money in 2023

                          Fulfilling Side Hustles for Good Money in 2023

                          5 Tips on How To Run Your First Charity Event

                          5 Tips on How To Run Your First Charity Event

                          Trending Tags

                          • Politics
                            OpenSecrets releases report on out-of-state donations’ rising role

                            OpenSecrets releases report on out-of-state donations’ rising role

                            Independent Sen. Krysten Sinema continues using liberal platforms to fundraise for 2024 reelection campaign

                            Independent Sen. Krysten Sinema continues using liberal platforms to fundraise for 2024 reelection campaign

                            Watchdog bites Ron DeSantis for alleged “soft money” campaign finance violation

                            Watchdog bites Ron DeSantis for alleged “soft money” campaign finance violation

                            Press Release: Over 30,000 White House financial disclosures to be made public in first for transparency and accountability

                            Press Release: Over 30,000 White House financial disclosures to be made public in first for transparency and accountability

                            Pro-Ron DeSantis super PAC to inherit state-level PAC war chest to support presidential run

                            Pro-Ron DeSantis super PAC to inherit state-level PAC war chest to support presidential run

                            Definition of ethics

                            The Interconnectedness of Racial Opinions and Ethics

                            Spyware firm NSO Group continues lobbying efforts to resume business-as-usual in the U.S.

                            Spyware firm NSO Group continues lobbying efforts to resume business-as-usual in the U.S.

                            Joe Manchin vows to block “radical climate agenda,” rakes in oil and gas industry contributions

                            Joe Manchin vows to block “radical climate agenda,” rakes in oil and gas industry contributions

                            Adam Schiff heads into California’s 2024 U.S. Senate race with a sizable cash advantage

                            Adam Schiff heads into California’s 2024 U.S. Senate race with a sizable cash advantage

                            Trending Tags

                            • Real Estate
                              Ways To Invest in Real Estate With No Experience

                              Ways To Invest in Real Estate With No Experience

                              How To Make Your Rental Property More Eco-Friendly

                              How To Make Your Rental Property More Eco-Friendly

                              Things To Consider Before Investing in Real Estate Overseas

                              Things To Consider Before Investing in Real Estate Overseas

                              Incredible Areas in Florida To Buy a Vacation Home

                              Incredible Areas in Florida To Buy a Vacation Home

                              Helpful Home Staging Tips for Virtual Tours

                              Helpful Home Staging Tips for Virtual Tours

                              Ways To Decorate and Design a Lake House

                              Ways To Decorate and Design a Lake House

                              Challenges To Managing a Rental Property

                              Challenges To Managing a Rental Property

                              The Best Landlord: How To Show Tenants You Care

                              The Best Landlord: How To Show Tenants You Care

                              The Best Locations To Invest in a Second Home

                              The Best Locations To Invest in a Second Home

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                              Is Legislation to Safeguard Americans Against Superbugs a Boondoggle or Breakthrough?

                              by Staff Writer
                              February 1, 2023
                              in Health
                              Is Legislation to Safeguard Americans Against Superbugs a Boondoggle or Breakthrough?
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                              By Liz Szabo and Arthur Allen

                              With time running out in the 2022 congressional session, a bipartisan coalition of lawmakers and infectious disease specialists is scrambling to pass a bill aimed at spurring the development of antibiotics to combat the deadly spread of drug-resistant pathogens.

                              The PASTEUR Act, as amended, would provide $6 billion in federal funding over several years to give drugmakers incentive to develop and manufacture lifesaving medications for the small but growing number of infections highly resistant to antibiotics.

                              A range of supporters in the health care and drug sectors say the measure would fix the “broken market” for antibiotics by providing stable funding for an industry that tends to focus its research on areas considered good business opportunities. In recent years, most major drug companies have abandoned antibiotic development due to lackluster sales, and several smaller ones involved in the work have declared bankruptcy.

                              But the measure also has staunch critics in the medical community who deride it as a multibillion-dollar boondoggle and giveaway to Big Pharma. They argue it won’t solve the longer-term problem of relying on profit as the primary motive to discover and develop antibiotics.

                              “This is a very clever maneuver to get the taxpayers to bail out an industry that’s foundering,” said Dr. Brad Spellberg, an infectious disease specialist and the chief medical officer at the Los Angeles County+USC Medical Center. “If the government is going to spend money on this, it should spend it smartly.”

                              The PASTEUR Act, which stands for Pioneering Antimicrobial Subscriptions to End Upsurging Resistance, was introduced by Sens. Michael Bennet, a Colorado Democrat, and Todd Young, an Indiana Republican, and in the House by Reps. Mike Doyle, a Pennsylvania Democrat, and Drew Ferguson, a Georgia Republican. It has more than 65 bipartisan co-sponsors across both chambers.

                              People for and against the bill agree that antimicrobial resistance is a critical problem the federal government needs to address. Superbugs that can’t be treated kill more than 35,000 Americans and an estimated 1.27 million people worldwide each year.

                              While pharmaceutical companies can make billions on medications that patients take for months or years, such as cancer therapies and cholesterol-lowering drugs, the industry often loses money on antibiotics, which are prescribed for only a few days or weeks, said Amanda Jezek, senior vice president for public policy and government relations at the Infectious Diseases Society of America.

                              Hospitals are trying to administer fewer antibiotics, whose use stimulates the growth of resistant organisms, and are particularly hesitant to employ newer antibiotics that target bugs highly resistant to drugs. That’s because such bacteria infect a minority of patients, and using the new drugs widely would only cause more mutations and resistance, Jezek said.

                              “When someone makes a new antibiotic, the first thing that infectious disease doctors say is, ‘Don’t use it,’” said Dr. Amesh Adalja, a senior scholar at the Johns Hopkins University Center for Health Security, who helps oversee antibiotic use at his hospital. “We need to save it until we really need it, because we don’t want to lose this drug.”

                              Instead of paying by the pill for antibiotics — a practice that encourages companies to promote their use — the PASTEUR Act would allow the federal government to advance lump sums for promising FDA-approved drugs that could then be administered to patients covered by government insurance programs such as Medicare and Medicaid. Such payments would provide manufacturers enough income to cover their costs for these drugs, even if they were rarely used.

                              But critics, including Public Citizen, say the PASTEUR Act offers the pharmaceutical industry what amounts to a windfall, without standards rigorous enough to ensure that new drugs are really safer and more effective than existing ones. And they cite a recent study that showed the vast majority of hospital deaths in patients with invasive bacterial infections were caused by treatable bugs, often in very old or frail patients.

                              Opponents also argue that drugmakers already have access to financial incentives to create antibiotics. Federal agencies including the National Institutes of Health and the Biomedical Advanced Research and Development Authority have invested hundreds of millions of dollars during the past decade in antibiotics research. Drugmakers also have access to financing from nonprofits such as CARB-X and Wellcome, as well as public-private partnerships such as the AMR Action Fund.

                              Congress and the FDA in recent years have made it easier for companies to get antibiotics approved and extend their marketing exclusivity.

                              The problem is not funding, but rather a lack of vigorous approval standards at the FDA, said Dr. Reshma Ramachandran, an assistant professor at the Yale School of Medicine.

                              The FDA approved 15 new antimicrobial drugs between 2016 and 2019. But a recently published study indicates these drugs often appear no more effective than older medications, even as companies charge up to 100 times more for them.

                              That explains why these drugs don’t sell, said Dr. John Powers, a former FDA official, clinical professor at George Washington University School of Medicine, and one of the study’s authors. “Insurers aren’t paying, doctors aren’t using them, because the evidence doesn’t show patients do better on them than older drugs.”

                              Powers argued that FDA reviews of new antibiotics don’t put enough emphasis on how they benefit patients. In one clinical trial of cefiderocol, for example, the drug was better at killing bacteria, but 34% of patients taking it died, compared with 18% taking older drugs. The FDA approved cefiderocol under a policy that allows approval of new drugs even if trials show they are less effective than old ones by as much as 10%.

                              “We need evidence these drugs improve patient outcomes,” Powers said. “They may kill more bacteria, but doctors don’t treat bacteria, doctors treat patients.”

                              Spellberg and other researchers have proposed an alternative. A federally funded nonprofit, or several nonprofits, endowed with $1 billion to $2 billion, could fund antibiotic research for decades, Spellberg predicted. A board made up of patient advocates, doctors, industry representatives, and others would regularly update an official list of which pathogens to target, aiming to ensure taxpayer dollars are being used where most needed.

                              Each nonprofit would include microbiologists, medical chemists, and pharmacologists “all under one roof,” Spellberg added. “They would not focus on one drug, per se. They would focus on discovering and developing new, impactful technologies.”

                              Supporters counter that the PASTEUR Act already includes built-in quality controls.

                              The bill would create a committee, similar to the board that Spellberg proposes, to identify the most dangerous superbugs. PASTEUR also would fund $500 million in federal grants to help hospitals improve stewardship of antibiotics — programs that manage their use with an eye to preventing the spread of resistant organisms — prioritizing rural and safety-net hospitals that serve low-income patients.

                              The United Kingdom has adopted a similar program, which supporters hope could demonstrate the effectiveness of subscription models.

                              Even supporters of PASTEUR, such as Dr. Thomas Frieden, a former director of the Centers for Disease Control and Prevention, note that antimicrobial resistance is a complex, long-term problem to be attacked on multiple fronts.

                              Hospital controls on antibiotic use have dramatically reduced the prevalence of one class of “nightmare bacteria,” the carbapenem-resistant Enterobacterales. Other tools, such as new vaccines, could reduce bacterial threats, he said. Doctors also could prescribe fewer antibiotics if they had rapid tests to allow them to quickly distinguish between viral and bacterial infections, and to determine which bacteria have mutations requiring a special approach.

                              “The idea here is not to come up with one superior best antibiotic,” said Dr. Cornelius Clancy, a University of Pittsburgh professor of medicine who supports the PASTEUR Act. “The point is to have a pipeline.”

                              This story was produced by KHN (Kaiser Health News), a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

                              KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

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